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More research is needed to further characterize the contribution of gender roles to the relationship between sex, gender, and pain. The results from 22 studies that examined sex differences in experimental heat pain are presented in the upper portion of Table 6. All of the studies used some form of contact heat with the exception of one study that used hot water immersion.360 Also, the forearm was the most common site for stimulus application. The vast majority of studies reported that females were more sensitive to heat pain than males. For the studies examining behavioral measures of heat pain sensitivity, 81% (12/17), and 94% (15/16) of the studies reported lower thresholds and tolerances, respectively, in females. Females were also found to rate heat pain as more intense and unpleasant in the majority of studies that included a suprathreshold protocol (7/9, 78%), and one study found that females required lower temperatures to evoke moderate pain.411 Overall, the hypothesis that heat pain sensitivity differs as a function of sex has been supported.
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- Several studies have addressed whether physical or psychological interventions differentially influence pain responses in men versus women, and these studies are summarized in the lower portion of Table 10.
- Differences in cerebral activation between males and females have been evaluated in a number of studies.
- In addition, differentiated Sertoli cells express anti-Müllerian hormone, which is required for Müllerian duct regression and differentiation of male genitalia14).
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- In the next step, two additional carbon atoms are removed by the CYP17A1 (17α-hydroxylase/17,20-lyase) enzyme in the endoplasmic reticulum to yield a variety of C19 steroids.[157] In addition, the 3β-hydroxyl group is oxidized by 3β-hydroxysteroid dehydrogenase to produce androstenedione.
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Using this approach, Hamberg and colleagues177 found that when the neck pain case was a woman, female and male medical students were more likely to provide nonspecific somatic diagnoses, address psychosocial variables in the history, and to prescribe analgesic and psychoactive medications. This review of recent clinical and epidemiologic findings generally indicates that women are at increased risk for many chronic pain conditions, and women tend to report higher levels of acute procedural pain. These sex differences appear smaller (or nonexistent) in children and appear to emerge or increase in magnitude during adolescence. Inevitably, these sex differences in clinical pain are driven by multiple biopsychosocial factors, which will be discussed below. We have previously suggested that sex differences in nociceptive processing, which would be manifested in responses to experimentally induced pain, represent one potentially important contributing factor.